What is a membrane stabilizing agent that is also an anticonvulsant?


What is a membrane stabilizing agent that is also an anticonvulsant?

Valproic acid (Depakote, Depakene, Depacon, Stavzor) This agent may also potentiate postsynaptic GABA responses, affect potassium channels, or exert a direct membrane-stabilizing effect.

What are membrane stabilizing agents?

Membrane stabilization is the method through which local anesthetics work. They block the propagation of action potentials across nerve cells, thereby producing a nerve block. Some beta-blockers also possess what is referred to as membrane stabilizing activity (MSA).

Which drug is membrane stabilizing agent?

Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane-stabilizing activity (MSA; eg, the quinidine-like effects of the class IA antidysrhythmic effects).

Which is membrane stabilizing agent used to treat arrhythmia?

Antiarrhythmic Drugs The membrane-stabilizing effects of propranolol have antiarrhythmic effects in addition to those due to β-adrenergic receptor blockade. Propranolol decreases automaticity and conduction velocity and increases refractoriness.

Which antiarrhythmic drug also has anticonvulsant properties?

Lidocaine and mexiletine showed the anticonvulsant activity not only in animal models, but also in patients with partial seizures. Among beta-blockers (class II AADs), propranolol was anticonvulsant in models for generalized tonic-clonic and complex partial seizures, but not for myoclonic convulsions.

Which drug is an antiarrhythmic?

Antiarrhythmic drugs

  • amiodarone (Cordarone, Pacerone)
  • flecainide (Tambocor)
  • ibutilide (Corvert), which can only be given through IV.
  • lidocaine (Xylocaine), which can only be given through IV.
  • procainamide (Procan, Procanbid)
  • propafenone (Rythmol)
  • quinidine (many brand names)
  • tocainide (Tonocarid)

What are stabilizers used for?

Stabilizers are substances that increase stability and thickness by helping foods remain in an emulsion and retain physical characteristics. Ingredients that normally do not mix, such as oil and water, need stabilizers. Many low-fat foods are dependent on stabilizers.

Is lidocaine a membrane stabilizer?

In this sense not only classical membrane stabilizing agents such as quinidine- or lidocaine-type drugs are antiarrhythmic; so are the very heterogeneous group of agents defined as calcium antagonists or the interventions changing the phospholipid composition of the cardiac cell membrane, such as a linoleic-acid rich …

What is intrinsic sympathomimetic?

Intrinsic sympathomimetic activity (ISA) characterizes a group of beta blockers that are able to stimulate beta-adrenergic receptors (agonist effect) and to oppose the stimulating effects of catecholamines (antagonist effect) in a competitive way.

What do you mean by anticonvulsant?

A drug or other substance used to prevent or stop seizures or convulsions. Also called antiepileptic.

What is anticonvulsant effect?

Anticonvulsants suppress the excessive rapid firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain. Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid (GABA) function.

What kind of medication is a membrane stabilizer?

Nonopioid medications, often referred to as adjuvant medications, can take the form of amine reuptake inhibitors, such as the tricyclic antidepressants (TCAs); neuronal membrane stabilizers, such as the sodium and calcium channel–blocking anticonvulsants; nonsteroidal anti-inflammatory drugs (NSAIDs); topical analgesics; and muscle relaxants.

What is the membrane stabilizing effect of beta blockers?

Membrane stabilizing effect. Some beta-blockers also possess what is referred to as membrane stabilizing activity (MSA). This effect is similar to the membrane stabilizing activity of sodium channel blockers that represent Class I antiarrhythmics. MSA agents produced by beta-blockers reduce the increase of cardiac action potential,…

How does phenytoin work as a membrane stabilizing agent?

Phenytoin exerts its membrane-stabilizing effect by blocking sodium channels, and it is generally held that it reduces neuronal excitability of pain fibers by this mechanism. Phenytoin was the first drug to be used for trigeminal neuralgia, but there is no randomized, controlled trial on the use of the agent for this condition.

What are the side effects of membrane stabilizing effect?

Mechanism of effect: structural similarity to lidocaine, membrane-stabilising effect on peripheral nerves and on a spinal and central and reticular level. Dosage: daily dose 3 times 50–150 mg. Side effects: tiredness, dizziness, nausea, mouth dryness, increase in liver enzymes.

About the author

Add Comment

By Admin

Your sidebar area is currently empty. Hurry up and add some widgets.