What is the term for the gap between adjacent foot processes in the glomerulus?

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What is the term for the gap between adjacent foot processes in the glomerulus?

The gaps between these endothelial cells are called fenestrae. The walls have a unique structure: there are pores between the cells that allow water and soluble substances to exit, and after passing through the glomerular basement membrane, and between podocyte foot processes, enter the capsule as ultrafiltrate.

What is fenestration in the kidney?

GEnC fenestrations are transcytoplasmic holes, specialized for their unique role as a prerequisite for filtration across the glomerular capillary wall.

What are filtration slits made of?

Filtration slit diaphragms are composed of nephrin, a cell adhesion molecule of the immunoglobulin superfamily, which controls slit size by its connection to podocyte actin.

What is juxtaglomerular apparatus?

The juxtaglomerular apparatus is the location of renin-secreting cells and the macula densa and lies at the junction between the loop of Henle and the distal nephron at which the tubule comes in close proximity to the afferent arteriole.16.

What is the meaning of podocytes?

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. The genetic or acquired impairment of podocytes may lead to foot process effacement (podocyte fusion or retraction), a morphological hallmark of proteinuric renal diseases.

Where is Bowman capsule located?

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The Bowman’s capsule is found in the outer part of the kidney, the cortex. Essentially, the capsule is a sealed, expanded sac at the end of the tubule, the rest of which elongates into a twisted and looped tubule in which urine is formed.

What are the layers of the filtration membrane?

The barrier consists of three layers: the vascular endothelium, the glomerular basement membrane and the slit diaphragm located between podocyte foot processes.

What does the fenestrated endothelium do?

fenestrations are the defining characteristic of the glomerular endothelial cell (GEnC) both morphologically and functionally. Furthermore, they perform a unique and vital physiological function in allowing filtration of the blood in the glomerulus.

How do podocytes perform filtration?

Podocytes are cells in the Bowman’s capsule in the kidneys that wrap around capillaries of the glomerulus. The pedicels wrap around the capillaries and leave slits between them. Blood is filtered through these slits, each known as a filtration slit or slit diaphragm or slit pore.

What is the function of podocytes in surrounding the glomerulus?

Podocytes play an important role in glomerular function. Together with endothelial cells of the glomerular capillary loop and the glomerular basement membrane they form a filtration barrier. Podocytes cooperate with mesangial cells to support the structure and function of the glomerulus.

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